San Diego Padres third base coach Matt Williams has been diagnosed with colon cancer, manager Bob Melvin told reporters Wednesday.

Williams will be with the team on opening day Thursday but will be absent afterward.

The 57-year-old man was diagnosed three weeks ago and is scheduled to undergo surgery on Friday. His spring training physical revealed a low red blood cell count, which resulted in additional tests showing a mass in his colon.

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Juan Soto #22 of the San Diego Padres reacts after his two-run home run off third base coach Matt Williams #18 during the fifth inning against the Philadelphia Phillies in game four of the National League Championship Series at Citizens Bank Park on October 22, 2022 in Philadelphia, Pennsylvania. (Mike Ehrman/Getty Images)

Mike Shildt will take his place on an interim basis, while Williams’ return this season is not ruled out.

Williams joined the Padres’ coaching staff prior to the 2022 season and previously coached third base under Melvin with the Oakland Athletics. He managed the Washington Nationals in 2014 and 2015.

He spent 17 years in the Major Leagues, playing for the San Francisco Giants, Arizona Diamondbacks, and Cleveland Rangers.

SAN FRANCISCO, CALIFORNIA - AUGUST 31: Third base coach Matt Williams #18 of the San Diego Padres looks on against the San Francisco Giants in the top of the fourth inning at Oracle Park on August 31, 2022 in San Francis, Calif.

SAN FRANCISCO, CALIFORNIA – AUGUST 31: Third base coach Matt Williams #18 of the San Diego Padres looks on against the San Francisco Giants in the top of the fourth inning at Oracle Park on August 31, 2022 in San Francis, Calif. (Thearon W. Henderson/Getty Images)

He hit 43 home runs in the strike-shortened 1994 season en route to a second-place National League MVP behind Jeff Bagwell. Williams also won four Gold Glove Awards at third base and was named an All-Star five times. He also finished third in National League MVP voting in 1999 and sixth in both 1990 and 1993.

Josh Bell #24 of the San Diego Padres celebrates with third base coach Matt Williams #18 as he rounds the bases after hitting a home run in the second inning of Game 2 of the NLCS between the Philadelphia Phillies and the San Diego Padres Diego at Petco Park on October 19, 2022 in San Diego, California.

Josh Bell #24 of the San Diego Padres celebrates with third base coach Matt Williams #18 as he rounds the bases after hitting a home run in the second inning of Game 2 of the NLCS between the Philadelphia Phillies and the San Diego Padres Diego at Petco Park on October 19, 2022 in San Diego, California. (Daniel Shirey/MLB Photos via Getty Images)

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The Padres open their season at Coors Field against the Colorado Rockies.